Asymmetric Syntheses of 8-Oxabicyclo[3,2,1]octanes: A Cationic Cascade Cyclization
نویسندگان
چکیده
منابع مشابه
Asymmetric syntheses of 8-oxabicyclo[3,2,1]octanes: a cationic cascade cyclization.
tropane alkaloids, and consequently there is an increasing interest in their potential pharmaceutical use, particularly against cocaine abuse. Compelled by the interesting biological activities of 8oxatropanes, many groups have embarked on the search for new methodologies to construct this bicyclic structure. For example, Molander and co-workers have reported a Lewis acid promoted double allyla...
متن کاملAsymmetric oxidative cation/olefin cyclization of polyenes: evidence for reversible cascade cyclization.
The biosynthesis of cyclic terpenes from polyene precursors by cyclase enzymes is one of nature’s most elegant chemical transformations.[1] The ease with which nature creates complex molecular architectures from achiral precursors has motivated efforts to develop similarly powerful synthetic methodologies.[2] Alimited number of asymmetric methods have been developed,[3] including the notable Br...
متن کاملAsymmetric organocatalysis in natural product syntheses.
Now welcome, the most inspiring book today from a very professional writer in the world, asymmetric organocatalysis in natural product syntheses. This is the book that many people in the world waiting for to publish. After the announced of this book, the book lovers are really curious to see how this book is actually. Are you one of them? That's very proper. You may not be regret now to seek fo...
متن کاملSyntheses and DNA binding of new cationic porphyrin-tetrapeptide conjugates.
Recently cationic porphyrin-peptide conjugates were synthesized to enhance the cellular uptake of porphyrins or deliver the peptide moiety to the close vicinity of nucleic acids. DNA binding of such compounds was not systematically studied yet. We synthesized two new porphyrin-tetrapeptide conjugates which can be considered as a typical monomer unit corresponding to the branches of porphyrin-po...
متن کاملEnantioselective Cascade Cyclization/Protodemetalation of Polyenes with N3Pt2+ Catalysts
The combination of the N-based pincer ligand PyBOX with Pt2+ leads to new catalysts for the enantioselective cycloisomerization of dienyl- and trienyl-ols. The mechanistic combination of electrophilic cyclization followed by rapid protodemetalation is surprising and leads to a powerful construct for developing new reactions.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2012
ISSN: 0044-8249
DOI: 10.1002/ange.201202699